This module provides integration of IIPImage to Drupal + proper image converting.
"IIPImage is an advanced high-performance feature-rich imaging server system for web-based streamed viewing and zooming of ultra high-resolution images. It is designed to be fast and bandwidth-efficient with low processor and memory requirements. The system can comfortably handle gigapixel size images as well as advanced image features such as both 8 and 16 bit depths, CIELAB colorimetric images and scientific imagery such as multispectral images."
You have to embed Fast CGI module within a host server such as Apache, Lighttpd, MyServer or Nginx.
So, eventually in your root there should be a folder called 'fcgi-bin' with 'iipsrv.fcgi' file in there.
You'll find a documentation about installation of FCGI module for your server here: http://iipimage.sourceforge.net/documentation/server/