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This module goes to great lengths to implement generic-purpose loading of the site's pages via Ajax, with the possibility to create region(s) that will be exempt from such loading. A concrete example of using this functionality is putting a persistent audio player on your website that would continue playing as the user browses the pages.
The Edgecast module connects your Drupal site to the CDN so that when you edit content the CDN knows to update it's cache quicker than the standard expiry time you've defined (usually hours or days