JUpload integrates the GPL license, Java based JUpload allowing Drupal users to upload very large files (> 2GB). Unlike uploaders written in Flash, Silverlight, or HTML5, Java does not have client side issues files larger than 2GB. Using FTP eliminates issues with PHP's file upload limits receiving files as an HTTP post.
This module was developed for UPTV in Urbana, IL. Their UC2B Project is wiring residential homes and anchor institutions with 1GB fiber for < $30 a month. With this type of broadband available, the public access station wanted to be able to accept extremely large files without having to train members to use an FTP client.
Some background on dealing with very large file uploads: