I had lots of little problems to get the environment together under Server 2008, but now the final two fixes made the stuff relay running.
There are some good screencasts to setup PHP and mySQL so I skip that and I also skip the drupal 6.x unzipping.
But now ther comes the problems for a few of us (or lets say most of us)
The problem is not a real drupal one and not a mysql one. Its a cookie problem with the multiple sessions. I have installed to fixes, which will be in the upcomming SP2 for 2008 (which is yet only as a beta available, which I do not recommend).
here is the 2 KBs you need to follow (or just install the mentioned fixes):
get those two installed and you will have issues for adding users, not installing the Drupal or not accepting any updates solved under Server 2008 SP1
Problems and the solutions offerred in other nodes and topics did not help, because most of them are for VISTA and not for Server 2008.
Server 2008 is close to VISTA, but the hotfixes for VISTA wont work for the 2008 Server.
happy hack (cu on Drupal Con Cologne 18/18 Jan 2009)