Hello, I've almost finished working this site for one of my clientes: http://www.felafacs.org/ , it's using Drupal 4.6.3 and some custom modules, all the content is in spanish but an english version could be launched in the future.
Felafacs is an academic organization that includes communications faculties from many universities in America and Spain (most of them spanish speaking).
I implemented the design with PHP Template, XHTML and CSS based on mockups provided in Adobe Illustrator by my client's designer so I didn't have much control over the general look.
I created some custom modules so users can find other users by profiles (I created my own custom profiles based on profile.module), the three kind of users for this site are professionals, students and teachers, all of them for communications related careers.
There are several custom node types such as universities, graduate courses, seminars, etc.
I have modified simplenews.module so that each new user is given the opportunity to check a box and get subscribed to the site's newsletter at the registration point. The newsletter is using some HTML which is grabbed from one simple template file, the newsletter design is very simple HTML but it's possible to modify the HTML basic template and get something better.
I also did a little Flash with Actionscript so the administrator of the site, using banner.module, can upload up to 3 little banners and these are rotated on the sidebar using Flash.