Hi I am using panels 6.x-3.x-dev. Everything work great. One problem that we have been having is that randomly our homepage will just display a white screen. When I go into edit the homepage panel, all the content and sections are missing. The way I fix is by clearing the cache. The problem with that is that I am using this on a high traffic site and when I clear the cache the server load gets super high and I have to redirect traffic and load the page manually by ip to rebuild the cache. Any help is much appreciated.
A quick fix is to put this at the end of your page.tpl.php (after
<?php if (empty($content)) drupal_flush_all_caches(); ?>