Important known issues with the Panelizer 7.x-2.0 release:
Integration with features is a little bit dicey still. We need someone who really understands features to help fix this.
Panelizer does not support locking while the IPE does; this can cause IPE to appear to revert changes if it holds a lock and the backend is used to modify a panel.
There needs to be a better way to automatically enable the page manager variants needed.