Installed Drush on Vista and successfully used dl and en. Ran up and after downloading three modules, it failed the updatedb phase, suggesting to run updatedb. Running updatedb gave the same results, specifically:
The command could not be executed successfully (returned: 's' is not a recognized as an internal or external command, operable program or batch file., code: 1.
Finished performing updates
An error occurred at function : drush_core_updatedb
I ran update.php manually, and it updated fine (reporting a problem with one of the modules -- no big deal). Drush updatedb now reports correctly that there is nothing to update.
I'm not sure if I have a configuration, installation, user error, or actual bug, so I tagged this support request.