Does not work well with Memcache

Have been getting a lot of the following error when creating new callbacks after a site has already been cached using memcache:
The requested callback "%callback" defined by the "%module" module could not be loaded. Please check your configuration and try again.

After discussing and trouble shooting this, @marco has determined that it is because Memcache uses variables to determine cache validity. Because the JS module only bootstraps to the database level, which is before the callback hook information is returned, Memcache cannot properly return the correct cached (invalidated) hook info.