Updating OpenPublish 3-alpha3 site with drush 4.5 destroy data in profiles/openpublish directory.

OpenPublish 3-alpha3
Drupal 7.10
drush 4.5
PHP 5.3.10

After drush up I got an error

Warning: include(/var/www/openpublish.loc/html/profiles/openpublish/themes/omega/omega/templates/region.tpl.php): failed to open stream: No such file or directory in theme_render_template() (line 1382 of /var/www/openpublish.loc/html/includes/theme.inc).

Directory profiles/openpublish lost. In the directory drush-backups only empty /modules.

Well, it was just a test site.

Part of the log:

$drush -v up
... skipped...

Code updates will be made to drupal core.
WARNING:  Updating core will discard any modifications made to Drupal core files, most noteworthy among these are .htaccess and robots.txt.  If you have made any modifications to these files, please back them up before updating so that you can re-create your modifications in the updated version of the file.
Note: Updating core can potentially break your site. It is NOT recommended to update production sites without prior testing.

Do you really want to continue? (y/n): y
Executing: mkdir '/var/www/openpublish.loc/html/drupal-7.12'
Executing: svn info '/var/www/openpublish.loc/html/drupal-7.12'
Executing: bzr root '/var/www/openpublish.loc/html/drupal-7.12'
Executing: wget -P . 'http://ftp.drupal.org/files/projects/drupal-7.12.tar.gz'
Downloading drupal-7.12.tar.gz was successful.                                                                                                                                                    [notice]
Md5 checksum of drupal-7.12.tar.gz verified.                                                                                                                                                      [notice]
Executing: tar -C '/var/www/openpublish.loc/html' -xzf 'drupal-7.12.tar.gz'
Executing: tar -tf 'drupal-7.12.tar.gz'
Project drupal was updated successfully. Installed version is now 7.12.
Backups were saved into the directory /var/www/drush-backups/openpublish/20120207101718/drupal.                                                                                                [ok]
Rolling back update of Drupal core code ...                                                                                                                                                       [notice]
Executing: svn info 'drupal-7.12'
Executing: bzr root 'drupal-7.12'
Backups were restored successfully.                                                                                                                                                            [ok]
Rolling back update of Views Boxes code ...                                                                                                                                                       [notice]
...skipped...
Executing: svn info 'profiles/openpublish/modules/custom/apps'
Executing: bzr root 'profiles/openpublish/modules/custom/apps'
Backups were restored successfully.                                                                                                                                                            [ok]
Command dispatch complete                                                                                                                                                                         [notice]

Repeatedly:

$drush -v up
Initialized Drupal 7.10 root directory at /var/www/openpublish.loc/html                                                                                                                           [notice]
Initialized Drupal site default at sites/default                                                                                                                                                  [notice]
require_once(/var/www/openpublish.loc/html/profiles/openpublish/modules/contrib/entitycache/entitycache.module): failed to open stream: No such file or directory bootstrap.inc:3004           [warning]
Drush command terminated abnormally due to an unrecoverable error.                                                                                                                             [error]
Error: require_once(): Failed opening required '/var/www/openpublish.loc/html/profiles/openpublish/modules/contrib/entitycache/entitycache.module'
(include_path='.:/usr/share/pear:/usr/share/php') in /var/www/openpublish.loc/html/includes/bootstrap.inc, line 3004
ob_end_clean(): failed to delete buffer. No buffer to delete drush.php:184                                                                                                                        [notice]
Drush was not able to start (bootstrap) Drupal.                                                                                                                                                [error]
Hint: This error can only occur once the database connection has already been successfully initiated, therefore this error generally points to a site configuration issue, and not a problem
connecting to the database.

Drush was attempting to connect to : 
  Drupal version    : 7.10
  Site URI          : http://default
  Database driver   : mysql
  Database hostname : localhost
  Database username : openpublish
  Database name     : openpublish
  Database          : Connected
  Default theme     : frame
  Administration theme: rubik
  PHP configuration : /etc/php.ini
  Drush version     : 4.5
  Drush configuration: 
  Drush alias files : 
  Drupal root       : /var/www/openpublish.loc/html
  Site path         : sites/default
  Modules path      : sites/all/modules
  Themes path       : sites/all/themes
  File directory path: sites/default/files
  %paths            : Array

You can select another site with a working database setup by specifying the URI to use with the --uri parameter on the command line or $options['uri'] in your drushrc.php file.