Can Drupal handle something like a webcomic website

Like the subject says, can drupal be used to make something like penny-arcade.com, nuklearpower.com, or vgcats.com?
Basically what I need is something along the lines of CUSP (comic update script), where multiple users have the ability to easily upload images or flash files and post comments (possibly with avatars). Uploaded files should also be archived, preferably in a dropdown selection(for the love of god no thumbnails, please no thumbnails!).

So... Can Drupal manage this?