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We have a use-case where certain classes of anonymous users should be served cached pages, while others should not.
I would be able to handle this in hook_boot() if the order of the function calls were slightly different in _drupal_bootstrap().
Otherwise, I have to do some code lookups in settings.php and set $conf['cache'] = CACHE_DISABLED;
This page allows implementations of hook_boot() to modify $conf before the page cache load routine is sent.
Looking at the current code, I can see no reason why this is not the case now.