On the responsive builders in the panel layout tab I get
Uncaught TypeError: Cannot set property 'Layout' of undefined
Uncaught TypeError: Cannot set property 'bindClickDelete' of undefined

Turns out panels-base.js gets loaded after display_editor.js and layout.js. It gets even worse in conjunction with the responsive layout plugin if javascript aggregation is activated, as the editor won't even load.

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iwyg created an issue.