When using TinyMCE together with an nginx config based on Perusio the caption button in the WYSIWYG editor is broken. This is due to the fact that the url for the modal window is built using the non-clean url syntax:
file : Drupal.settings.basePath + 'index.php?q=caption_filter/tinymce',

The Perusio setup prevents direct callings to php files, including the index.php.
Other modules have this problem too, see #2052807: 404 error when using smiley wysiwyg with Perusio's nginx config as an example.

I'm not sure if this is a problem in this module or with the nginx configuration, but I thought it's best to report it anyways.

For a possible fix of this in the nginx config have a look at https://github.com/perusio/drupal-with-nginx/issues/129

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berliner created an issue.