Persistent Systems was incorporated as Persistent Systems Private Limited on May 30, 1990. It was subsequently converted into a public Limited company on September 17, 2007 with the name Persistent Systems Limited and a new certificate of incorporation was issued on September 28, 2007 from the RoC.

Shares in the company were listed on the National Stock Exchange of India in March 2010. The operations of Nagpur-based Infospectrum India Private, an outsourced private development of US company Infospectrum, were taken over by Persistent in February 2011.