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I show a Google+ album that contains HQ images.
As soon as these images are shown in the Lightbox, the quality is so much lower that it looks like the thumbnails are being scaled up.
I have the GD Toolkit installed and set to jpg quality of 100%, so that should not be the underlying issue?
Tiny update to the issue: not all - but most - images suffer from this, which makes it even more awkward.