Has anyone experienced any issues with Apache 2_2 and PhP 5

I get this error
"We were unable to use the MySQL database because the MySQL extension for PHP is not installed. Check your PHP.ini to see how you can enable it.

"

I came across this post
http://codewalkers.com/forum/index.php?action=displaythread&realm=defaul...

 RE: PHP 5 php_mysql.dll problem width mysql 4.x & 5.0 libmysql.dll      
Downgrade ...

I was trying to get Drupal 5 running PHP 5.2.0 with Apache 2.2 and had no luck with PHP & MySQL (kept getting the message "We were unable to use the MySQL database because the MySQL extension for PHP is not installed."). So eventually I just downgraded to PHP 5.0.5 and Apache 2.0. Evetything works fine now.  

Before I downgrade I was wondering if anyone came across this. If I run the same setup using IIS on the same codebase and my sql/php... it works fine