diff --git a/core/lib/Drupal/Core/Extension/ModuleHandler.php b/core/lib/Drupal/Core/Extension/ModuleHandler.php
index 05f1e4f..b040c18 100644
--- a/core/lib/Drupal/Core/Extension/ModuleHandler.php
+++ b/core/lib/Drupal/Core/Extension/ModuleHandler.php
@@ -677,12 +677,14 @@ public static function parseDependency($dependency) {
     $p_major = '(?<major>\d+)';
     // By setting the minor version to x, branches can be matched.
     $p_minor = '(?<minor>(?:\d+|x)(?:-[A-Za-z]+\d+)?)';
+    // @todo@ if $p_minor is 'x', then there's no patch version for sure. Since we don't support 8.x.1 and 8.x.x is redundant with core compatibility check.
+    $p_patch = '(?<patch>(?:\d+|x)(?:-[A-Za-z]+\d+)?)';
     $parts = explode('(', $dependency, 2);
     $value['name'] = trim($parts[0]);
     if (isset($parts[1])) {
       $value['original_version'] = ' (' . $parts[1];
       foreach (explode(',', $parts[1]) as $version) {
-        if (preg_match("/^\s*$p_op\s*$p_core$p_major\.$p_minor/", $version, $matches)) {
+        if (preg_match("/^\s*$p_op\s*$p_core$p_major\.$p_minor(\.$p_patch)?/", $version, $matches)) {
           $op = !empty($matches['operation']) ? $matches['operation'] : '=';
           if ($matches['minor'] == 'x') {
             // Drupal considers "2.x" to mean any version that begins with
@@ -700,7 +702,11 @@ public static function parseDependency($dependency) {
               $op = '>=';
             }
           }
-          $value['versions'][] = array('op' => $op, 'version' => $matches['major'] . '.' . $matches['minor']);
+          $version = $matches['major'] . '.' . $matches['minor'];
+          if (isset($matches['patch'])) {
+            $version .= '.' . $matches['patch'];
+          }
+          $value['versions'][] = array('op' => $op, 'version' => $version);
         }
       }
     }
diff --git a/core/modules/system/src/Tests/Module/DependencyTest.php b/core/modules/system/src/Tests/Module/DependencyTest.php
index e9162a8..a57ba23 100644
--- a/core/modules/system/src/Tests/Module/DependencyTest.php
+++ b/core/modules/system/src/Tests/Module/DependencyTest.php
@@ -82,6 +82,21 @@ function testIncompatibleModuleVersionDependency() {
   }
 
   /**
+   * Tests enabling a module that depends on an incompatible semantic version of a module.
+   */
+  function testIncompatibleModuleSemanticVersionDependency() {
+    // Test that the system_incompatible_module_semantic_version_dependencies_test is
+    // marked as having an incompatible dependency.
+    $this->drupalGet('admin/modules');
+    $this->assertRaw(t('@module (<span class="admin-missing">incompatible with</span> version @version)', array(
+      '@module' => 'System (>= 8.1.999)',
+      '@version' => \Drupal::VERSION,
+    )), 'A module that depends on an incompatible semantic version of a module is marked as such.');
+    $checkbox = $this->xpath('//input[@type="checkbox" and @disabled="disabled" and @name="modules[Testing][system_incompatible_module_semantic_version_dependencies_test][enable]"]');
+    $this->assert(count($checkbox) == 1, 'Checkbox for the module is disabled.');
+  }
+
+  /**
    * Tests enabling a module that depends on a module with an incompatible core version.
    */
   function testIncompatibleCoreVersionDependency() {
diff --git a/core/modules/system/tests/modules/system_incompatible_module_semantic_version_dependencies_test/system_incompatible_module_semantic_version_dependencies_test.info.yml b/core/modules/system/tests/modules/system_incompatible_module_semantic_version_dependencies_test/system_incompatible_module_semantic_version_dependencies_test.info.yml
new file mode 100644
index 0000000..4a1a72d
--- /dev/null
+++ b/core/modules/system/tests/modules/system_incompatible_module_semantic_version_dependencies_test/system_incompatible_module_semantic_version_dependencies_test.info.yml
@@ -0,0 +1,8 @@
+name: 'System incompatible module semantic version dependencies test'
+type: module
+description: 'Support module for testing system dependencies.'
+package: Testing
+version: VERSION
+core: 8.x
+dependencies:
+  - 'drupal:system (>= 8.1.999)'