diff --git a/core/modules/layout_builder/src/Entity/LayoutBuilderEntityViewDisplay.php b/core/modules/layout_builder/src/Entity/LayoutBuilderEntityViewDisplay.php
index 2582d5c7ed..ccf6b203ee 100644
--- a/core/modules/layout_builder/src/Entity/LayoutBuilderEntityViewDisplay.php
+++ b/core/modules/layout_builder/src/Entity/LayoutBuilderEntityViewDisplay.php
@@ -2,6 +2,7 @@
 
 namespace Drupal\layout_builder\Entity;
 
+use Drupal\Component\Plugin\Definition\PluginDefinitionInterface;
 use Drupal\Component\Plugin\DependentPluginInterface;
 use Drupal\Component\Plugin\PluginInspectionInterface;
 use Drupal\Component\Utility\NestedArray;
@@ -10,6 +11,7 @@
 use Drupal\Core\Entity\FieldableEntityInterface;
 use Drupal\Core\Plugin\Context\Context;
 use Drupal\Core\Plugin\Context\ContextDefinition;
+use Drupal\Core\Plugin\Definition\DependentPluginDefinitionInterface;
 use Drupal\Core\StringTranslation\TranslatableMarkup;
 use Drupal\field\Entity\FieldConfig;
 use Drupal\field\Entity\FieldStorageConfig;
@@ -201,6 +203,7 @@ public function calculateDependencies() {
     parent::calculateDependencies();
 
     foreach ($this->getSections() as $delta => $section) {
+      $this->calculatePluginDependencies($section->getLayout());
       foreach ($section->getComponents() as $uuid => $component) {
         $this->calculatePluginDependencies($component->getPlugin());
       }
@@ -218,6 +221,15 @@ public function onDependencyRemoval(array $dependencies) {
     // Loop through all components and determine if the removed dependencies are
     // used by their plugins.
     foreach ($this->getSections() as $delta => $section) {
+      $layout_dependencies = $this->getPluginDependencies($section->getLayout());
+      $layout_removed_dependencies = $this->getPluginRemovedDependencies($layout_dependencies, $dependencies);
+      if ($layout_removed_dependencies) {
+        // @todo Allow the plugins to react to their dependency removal in
+        //   https://www.drupal.org/project/drupal/issues/2579743.
+        $this->removeSection($delta);
+        $changed = TRUE;
+      }
+
       foreach ($section->getComponents() as $uuid => $component) {
         $plugin_dependencies = $this->getPluginDependencies($component->getPlugin());
         $component_removed_dependencies = $this->getPluginRemovedDependencies($plugin_dependencies, $dependencies);
@@ -244,11 +256,20 @@ public function onDependencyRemoval(array $dependencies) {
    * @todo Replace this in https://www.drupal.org/project/drupal/issues/2939925.
    */
   protected function getPluginDependencies(PluginInspectionInterface $instance) {
+    $dependencies = [];
     $definition = $instance->getPluginDefinition();
-    $dependencies['module'][] = $definition['provider'];
-    // Plugins can declare additional dependencies in their definition.
-    if (isset($definition['config_dependencies'])) {
-      $dependencies = NestedArray::mergeDeep($dependencies, $definition['config_dependencies']);
+    if ($definition instanceof PluginDefinitionInterface) {
+      $dependencies['module'][] = $definition->getProvider();
+      if ($definition instanceof DependentPluginDefinitionInterface && $config_dependencies = $definition->getConfigDependencies()) {
+        $dependencies = NestedArray::mergeDeep($dependencies, $config_dependencies);
+      }
+    }
+    elseif (is_array($definition)) {
+      $dependencies['module'][] = $definition['provider'];
+      // Plugins can declare additional dependencies in their definition.
+      if (isset($definition['config_dependencies'])) {
+        $dependencies = NestedArray::mergeDeep($dependencies, $definition['config_dependencies']);
+      }
     }
 
     // If a plugin is dependent, calculate its dependencies.
diff --git a/core/modules/layout_builder/tests/src/Functional/LayoutBuilderTest.php b/core/modules/layout_builder/tests/src/Functional/LayoutBuilderTest.php
index d14007aadf..4dc9a85d0d 100644
--- a/core/modules/layout_builder/tests/src/Functional/LayoutBuilderTest.php
+++ b/core/modules/layout_builder/tests/src/Functional/LayoutBuilderTest.php
@@ -16,6 +16,7 @@ class LayoutBuilderTest extends BrowserTestBase {
    */
   public static $modules = [
     'layout_builder',
+    'layout_test',
     'block',
     'node',
   ];
@@ -205,9 +206,26 @@ public function testPluginDependencies() {
     $page->fillField('label', 'My Menu');
     $page->fillField('id', 'mymenu');
     $page->pressButton('Save');
+    $this->drupalGet('admin/structure/menu/add');
+    $page->fillField('label', 'My Menu');
+    $page->fillField('id', 'myothermenu');
+    $page->pressButton('Save');
+
+    $this->drupalGet('admin/structure/types/manage/bundle_with_section_field/display-layout/default');
+    $assert_session->linkExists('Add Section');
+    $this->clickLink('Add Section');
+    $assert_session->linkExists('Layout plugin (with dependencies)');
+    $this->clickLink('Layout plugin (with dependencies)');
+    $assert_session->elementExists('css', '.layout--layout-test-dependencies-plugin');
+    $assert_session->elementExists('css', '.field--name-body');
+    $assert_session->linkExists('Save Layout');
+    $this->clickLink('Save Layout');
+    $this->drupalPostForm('admin/structure/menu/manage/myothermenu/delete', [], 'Delete');
+    $this->drupalGet('admin/structure/types/manage/bundle_with_section_field/display-layout/default');
+    $assert_session->elementNotExists('css', '.layout--layout-test-dependencies-plugin');
+    $assert_session->elementExists('css', '.field--name-body');
 
     // Add a menu block.
-    $this->drupalGet('admin/structure/types/manage/bundle_with_section_field/display-layout/default');
     $assert_session->linkExists('Add Block');
     $this->clickLink('Add Block');
     $assert_session->linkExists('My Menu');
diff --git a/core/modules/system/tests/modules/layout_test/src/Plugin/Layout/LayoutTestDependenciesPlugin.php b/core/modules/system/tests/modules/layout_test/src/Plugin/Layout/LayoutTestDependenciesPlugin.php
new file mode 100644
index 0000000000..0aad55a36c
--- /dev/null
+++ b/core/modules/system/tests/modules/layout_test/src/Plugin/Layout/LayoutTestDependenciesPlugin.php
@@ -0,0 +1,34 @@
+<?php
+
+namespace Drupal\layout_test\Plugin\Layout;
+
+use Drupal\Component\Plugin\DependentPluginInterface;
+use Drupal\Core\Layout\LayoutDefault;
+
+/**
+ * Provides a plugin that contains config dependencies.
+ *
+ * @Layout(
+ *   id = "layout_test_dependencies_plugin",
+ *   label = @Translation("Layout plugin (with dependencies)"),
+ *   category = @Translation("Layout test"),
+ *   description = @Translation("Test layout"),
+ *   regions = {
+ *     "main" = {
+ *       "label" = @Translation("Main Region")
+ *     }
+ *   }
+ * )
+ */
+class LayoutTestDependenciesPlugin extends LayoutDefault implements DependentPluginInterface {
+
+  /**
+   * {@inheritdoc}
+   */
+  public function calculateDependencies() {
+    $dependencies = [];
+    $dependencies['config'][] = 'system.menu.myothermenu';
+    return $dependencies;
+  }
+
+}