diff --git a/core/modules/settings_tray/js/settings_tray.es6.js b/core/modules/settings_tray/js/settings_tray.es6.js
index a680115490..a50f45198d 100644
--- a/core/modules/settings_tray/js/settings_tray.es6.js
+++ b/core/modules/settings_tray/js/settings_tray.es6.js
@@ -5,7 +5,7 @@
  * @private
  */
 
-(function ($, Drupal) {
+(function ($, Drupal, drupalSettings) {
   const blockConfigureSelector = '[data-settings-tray-edit]';
   const toggleEditSelector = '[data-drupal-settingstray="toggle"]';
   const itemsToToggleSelector = '[data-off-canvas-main-canvas], #toolbar-bar, [data-drupal-settingstray="editable"] a, [data-drupal-settingstray="editable"] button';
@@ -164,6 +164,17 @@
         if (!('dialogOptions' in instance.options.data)) {
           instance.options.data.dialogOptions = {};
         }
+
+        if (drupalSettings.hasOwnProperty('settings_tray') && drupalSettings.settings_tray.hasOwnProperty('overridden_blocks')) {
+          Object.keys(drupalSettings.settings_tray.overridden_blocks).forEach(
+            (blockId) => {
+              if (instance.options.url.indexOf(`/admin/structure/block/manage/${blockId}/off-canvas`) !== -1) {
+                instance.options.url = drupalSettings.settings_tray.overridden_blocks[blockId];
+              }
+            },
+          );
+        }
+
         instance.options.data.dialogOptions.settingsTrayActiveEditableId = $(instance.element).parents('.settings-tray-editable').attr('id');
         instance.progress = { type: 'fullscreen' };
       });
@@ -253,4 +264,4 @@
       }
     },
   });
-}(jQuery, Drupal));
+}(jQuery, Drupal, drupalSettings));
diff --git a/core/modules/settings_tray/js/settings_tray.js b/core/modules/settings_tray/js/settings_tray.js
index 78c5b60382..9d7e80a1bf 100644
--- a/core/modules/settings_tray/js/settings_tray.js
+++ b/core/modules/settings_tray/js/settings_tray.js
@@ -5,7 +5,7 @@
 * @preserve
 **/
 
-(function ($, Drupal) {
+(function ($, Drupal, drupalSettings) {
   var blockConfigureSelector = '[data-settings-tray-edit]';
   var toggleEditSelector = '[data-drupal-settingstray="toggle"]';
   var itemsToToggleSelector = '[data-off-canvas-main-canvas], #toolbar-bar, [data-drupal-settingstray="editable"] a, [data-drupal-settingstray="editable"] button';
@@ -100,6 +100,15 @@
       if (!('dialogOptions' in instance.options.data)) {
         instance.options.data.dialogOptions = {};
       }
+
+      if (drupalSettings.hasOwnProperty('settings_tray') && drupalSettings.settings_tray.hasOwnProperty('overridden_blocks')) {
+        Object.keys(drupalSettings.settings_tray.overridden_blocks).forEach(function (blockId) {
+          if (instance.options.url.indexOf('/admin/structure/block/manage/' + blockId + '/off-canvas') !== -1) {
+            instance.options.url = drupalSettings.settings_tray.overridden_blocks[blockId];
+          }
+        });
+      }
+
       instance.options.data.dialogOptions.settingsTrayActiveEditableId = $(instance.element).parents('.settings-tray-editable').attr('id');
       instance.progress = { type: 'fullscreen' };
     });
@@ -153,4 +162,4 @@
       }
     }
   });
-})(jQuery, Drupal);
\ No newline at end of file
+})(jQuery, Drupal, drupalSettings);
\ No newline at end of file
diff --git a/core/modules/settings_tray/settings_tray.libraries.yml b/core/modules/settings_tray/settings_tray.libraries.yml
index de5c82c78d..11b55a478f 100644
--- a/core/modules/settings_tray/settings_tray.libraries.yml
+++ b/core/modules/settings_tray/settings_tray.libraries.yml
@@ -17,3 +17,4 @@ drupal.settings_tray:
     - core/drupal
     - core/jquery.once
     - core/drupal.ajax
+    - core/drupalSettings
diff --git a/core/modules/settings_tray/settings_tray.module b/core/modules/settings_tray/settings_tray.module
index af04450459..821f62c19c 100644
--- a/core/modules/settings_tray/settings_tray.module
+++ b/core/modules/settings_tray/settings_tray.module
@@ -10,6 +10,9 @@
 use Drupal\settings_tray\Block\BlockEntityOffCanvasForm;
 use Drupal\settings_tray\Form\SystemBrandingOffCanvasForm;
 use Drupal\settings_tray\Form\SystemMenuOffCanvasForm;
+use Drupal\block\Entity\Block;
+use Drupal\Core\Url;
+use Drupal\Core\EventSubscriber\MainContentViewSubscriber;
 
 /**
  * Implements hook_help().
@@ -48,6 +51,21 @@ function settings_tray_contextual_links_view_alter(&$element, $items) {
   }
 }
 
+/**
+ * Checks if a block has overrides.
+ *
+ * @param string $block_id
+ *   The ID of the block to check for overrides.
+ *
+ * @return bool
+ *   TRUE if the block has overrides otherwise FALSE.
+ */
+function _settings_tray_has_block_overrides($block_id) {
+  $block = Block::load($block_id);
+  $overrides = \Drupal::config($block->getEntityType()->getConfigPrefix() . '.' . $block->id())->getOverrides();
+  return !empty($overrides);
+}
+
 /**
  * Implements hook_block_view_alter().
  */
@@ -58,6 +76,27 @@ function settings_tray_block_view_alter(array &$build) {
   $build['#contextual_links']['settings_tray'] = [
     'route_parameters' => [],
   ];
+  $block_id = $build['#block']->id();
+  // If a block currently has configuration overrides it cannot be edited in the
+  // Settings Tray form.
+  if (_settings_tray_has_block_overrides($block_id)) {
+    $url = Url::fromRoute('settings_tray.overridden_block_warning')
+      ->setRouteParameter('block', $block_id)
+      ->setOptions(
+        [
+          'query' => [
+            MainContentViewSubscriber::WRAPPER_FORMAT => 'drupal_dialog.off_canvas',
+          ] + \Drupal::destination()->getAsArray(),
+        ]
+      );
+    // Store the URL to the overridden notice for this block in drupalSettings.
+    // This will be used in the Javascript function prepareAjaxLinks() to
+    // replace the URL to the Settings Tray edit form. We cannot use
+    // settings_tray_contextual_links_view_alter() to alter the URL because the
+    // contextual links will not be rebuilt for every context that could have
+    // configuration overrides.
+    $build['#attached']['drupalSettings']['settings_tray']['overridden_blocks'][$block_id] = $url->toString();
+  }
 }
 
 /**
diff --git a/core/modules/settings_tray/settings_tray.routing.yml b/core/modules/settings_tray/settings_tray.routing.yml
index 01109e4c79..c2f4f7c140 100644
--- a/core/modules/settings_tray/settings_tray.routing.yml
+++ b/core/modules/settings_tray/settings_tray.routing.yml
@@ -6,3 +6,10 @@ entity.block.off_canvas_form:
   requirements:
     _permission: 'administer blocks'
     _access_block_plugin_has_settings_tray_form: 'TRUE'
+settings_tray.overridden_block_warning:
+  path: '/admin/settings-tray-overridden/{block}'
+  defaults:
+    _controller: '\Drupal\settings_tray\Controller\OverriddenBlockConfig::overrideNotice'
+    _title_callback: '\Drupal\settings_tray\Block\BlockEntityOffCanvasForm::title'
+  requirements:
+    _permission: 'administer blocks'
diff --git a/core/modules/settings_tray/src/Controller/OverriddenBlockConfig.php b/core/modules/settings_tray/src/Controller/OverriddenBlockConfig.php
new file mode 100644
index 0000000000..f113f82070
--- /dev/null
+++ b/core/modules/settings_tray/src/Controller/OverriddenBlockConfig.php
@@ -0,0 +1,48 @@
+<?php
+
+namespace Drupal\settings_tray\Controller;
+
+use Drupal\block\BlockInterface;
+use Drupal\Core\StringTranslation\StringTranslationTrait;
+use Drupal\Core\Url;
+
+/**
+ * Controller to display overridden block notice and edit link.
+ *
+ * Overridden blocks cannot be overridden in Settings Tray functionality
+ * because there is not uniform method for edit any potential configuration
+ * override.
+ *
+ * @see
+ */
+class OverriddenBlockConfig {
+
+  use StringTranslationTrait;
+
+  /**
+   * Provides a notice for overridden blocks and a link to edit them.
+   *
+   * @param \Drupal\block\BlockInterface $block
+   *   The block that is overridden.
+   *
+   * @return array
+   *   The render array for the notice and block edit link.
+   */
+  public function overrideNotice(BlockInterface $block) {
+    return [
+      'message' => [
+        '#type' => 'markup',
+        '#markup' => '<p>' . $this->t('This block cannot be edited in the Settings Tray form because it has configuration overrides in effect.') . '</p>',
+      ],
+      'link' => [
+        '#type' => 'link',
+        '#title' => $this->t('Edit Block'),
+        '#url' => Url::fromRoute('entity.block.edit_form')
+          ->setRouteParameter('block', $block->id())
+          ->setOption('query', ['destination' => \Drupal::request()->get('destination')]),
+      ],
+    ];
+
+  }
+
+}
diff --git a/core/modules/settings_tray/tests/modules/settings_tray_override_test/settings_tray_override_test.info.yml b/core/modules/settings_tray/tests/modules/settings_tray_override_test/settings_tray_override_test.info.yml
new file mode 100644
index 0000000000..39fb56fa55
--- /dev/null
+++ b/core/modules/settings_tray/tests/modules/settings_tray_override_test/settings_tray_override_test.info.yml
@@ -0,0 +1,8 @@
+name: 'Configuration override test for Settings Tray'
+type: module
+package: Testing
+version: VERSION
+core: 8.x
+
+dependencies:
+  - settings_tray
diff --git a/core/modules/settings_tray/tests/modules/settings_tray_override_test/settings_tray_override_test.services.yml b/core/modules/settings_tray/tests/modules/settings_tray_override_test/settings_tray_override_test.services.yml
new file mode 100644
index 0000000000..b23035bde2
--- /dev/null
+++ b/core/modules/settings_tray/tests/modules/settings_tray_override_test/settings_tray_override_test.services.yml
@@ -0,0 +1,5 @@
+services:
+  settings_tray_override_test.overrider:
+    class: Drupal\settings_tray_override_test\ConfigOverrider
+    tags:
+      - { name: config.factory.override}
diff --git a/core/modules/settings_tray/tests/modules/settings_tray_override_test/src/ConfigOverrider.php b/core/modules/settings_tray/tests/modules/settings_tray_override_test/src/ConfigOverrider.php
new file mode 100644
index 0000000000..1ee59631c5
--- /dev/null
+++ b/core/modules/settings_tray/tests/modules/settings_tray_override_test/src/ConfigOverrider.php
@@ -0,0 +1,51 @@
+<?php
+
+namespace Drupal\settings_tray_override_test;
+
+use Drupal\Core\Cache\CacheableMetadata;
+use Drupal\Core\Config\ConfigFactoryOverrideInterface;
+use Drupal\Core\Config\StorageInterface;
+
+/**
+ * Provides an overridden block for Settings Tray testing.
+ *
+ * @see \Drupal\Tests\settings_tray\FunctionalJavascript\SettingsTrayBlockFormTest::testOverriddenDisabled()
+ */
+class ConfigOverrider implements ConfigFactoryOverrideInterface {
+
+
+  /**
+   * {@inheritdoc}
+   */
+  public function loadOverrides($names) {
+    $overrides = [];
+    if (TRUE || !empty($GLOBALS['config_test_run_module_overrides'])) {
+      if (in_array('block.block.overridden_block', $names)) {
+        $overrides = $overrides + ['block.block.overridden_block' => ['settings' => ['label' => 'ALL YOUR LABELS BELONG TO US']]];
+      }
+    }
+    return $overrides;
+  }
+
+  /**
+   * {@inheritdoc}
+   */
+  public function getCacheSuffix() {
+    return 'ConfigOverrider';
+  }
+
+  /**
+   * {@inheritdoc}
+   */
+  public function createConfigObject($name, $collection = StorageInterface::DEFAULT_COLLECTION) {
+    return NULL;
+  }
+
+  /**
+   * {@inheritdoc}
+   */
+  public function getCacheableMetadata($name) {
+    return new CacheableMetadata();
+  }
+
+}
diff --git a/core/modules/settings_tray/tests/src/FunctionalJavascript/SettingsTrayBlockFormTest.php b/core/modules/settings_tray/tests/src/FunctionalJavascript/SettingsTrayBlockFormTest.php
index fcfecde400..5480fd512b 100644
--- a/core/modules/settings_tray/tests/src/FunctionalJavascript/SettingsTrayBlockFormTest.php
+++ b/core/modules/settings_tray/tests/src/FunctionalJavascript/SettingsTrayBlockFormTest.php
@@ -2,6 +2,7 @@
 
 namespace Drupal\Tests\settings_tray\FunctionalJavascript;
 
+use Drupal\block\BlockInterface;
 use Drupal\block\Entity\Block;
 use Drupal\block_content\Entity\BlockContent;
 use Drupal\block_content\Entity\BlockContentType;
@@ -75,7 +76,7 @@ public function testBlocks($theme, $block_plugin, $new_page_text, $element_selec
     $page = $this->getSession()->getPage();
     $this->enableTheme($theme);
     $block = $this->placeBlock($block_plugin);
-    $block_selector = str_replace('_', '-', $this->getBlockSelector($block));
+    $block_selector = $this->getBlockCssSelector($block);
     $block_id = $block->id();
     $this->drupalGet('user');
 
@@ -267,8 +268,10 @@ protected function assertOffCanvasBlockFormIsValid() {
    * @param string $contextual_link_container
    *   The element that contains the contextual links. If none provide the
    *   $block_selector will be used.
+   * @param bool $confirm_form
+   *   Determines if the block form should be confirmed.
    */
-  protected function openBlockForm($block_selector, $contextual_link_container = '') {
+  protected function openBlockForm($block_selector, $contextual_link_container = '', $confirm_form = TRUE) {
     if (!$contextual_link_container) {
       $contextual_link_container = $block_selector;
     }
@@ -283,7 +286,10 @@ protected function openBlockForm($block_selector, $contextual_link_container = '
     $this->assertSession()->assertWaitOnAjaxRequest();
     $this->click($block_selector);
     $this->waitForOffCanvasToOpen();
-    $this->assertOffCanvasBlockFormIsValid();
+    if ($confirm_form) {
+      $this->assertOffCanvasBlockFormIsValid();
+    }
+
   }
 
   /**
@@ -321,7 +327,7 @@ public function testQuickEditLinks() {
       $this->enableTheme($theme);
 
       $block = $this->placeBlock($block_plugin);
-      $block_selector = str_replace('_', '-', $this->getBlockSelector($block));
+      $block_selector = $this->getBlockCssSelector($block);
       // Load the same page twice.
       foreach ([1, 2] as $page_load_times) {
         $this->drupalGet('node/' . $node->id());
@@ -577,4 +583,52 @@ protected function getTestThemes() {
     });
   }
 
+  /**
+   * Tests that the blocks with configuration overrides are disabled.
+   */
+  public function testOverriddenDisabled() {
+    $web_assert = $this->assertSession();
+    $overridden_text = 'This block cannot be edited in the Settings Tray form because it has configuration overrides in effect.';
+    $this->container->get('module_installer')->install(['settings_tray_override_test']);
+    // Test a overridden block does not show the form in the off-canvas dialog.
+    // @see \Drupal\settings_tray_override_test\ConfigOverrider
+    $overridden_block = $this->placeBlock('system_powered_by_block',
+      [
+        'id' => 'overridden_block',
+        'label_display' => 1,
+        'label' => 'This will be overridden.',
+      ]);
+    $this->drupalGet('user');
+    // Confirm the label is actually overridden.
+    $web_assert->elementContains('css', $this->getBlockCssSelector($overridden_block), 'ALL YOUR LABELS BELONG TO US');
+    $this->enableEditMode();
+    $this->openBlockForm($this->getBlockCssSelector($overridden_block), '', FALSE);
+    $web_assert->elementContains('css', self::OFF_CANVAS_CSS_SELECTOR, $overridden_text);
+
+    // Test a non-overridden block does show the form in the off-canvas dialog.
+    $block = $this->placeBlock('system_powered_by_block',
+      [
+        'label_display' => 1,
+        'label' => 'Labely label',
+      ]);
+    $this->drupalGet('user');
+    // Confirm the label is not overridden.
+    $web_assert->elementContains('css', $this->getBlockCssSelector($block), 'Labely label');
+    $this->openBlockForm($this->getBlockCssSelector($block));
+    $web_assert->elementNotContains('css', self::OFF_CANVAS_CSS_SELECTOR, $overridden_text);
+  }
+
+  /**
+   * Gets the CSS selector for a block.
+   *
+   * @param \Drupal\block\BlockInterface $block
+   *   The block.
+   *
+   * @return string
+   *   The CSS selector for the block.
+   */
+  protected function getBlockCssSelector(BlockInterface $block) {
+    return str_replace('_', '-', $this->getBlockSelector($block));
+  }
+
 }