diff --git a/core/modules/file/file.module b/core/modules/file/file.module
index 0484e44dd6..f136985529 100644
--- a/core/modules/file/file.module
+++ b/core/modules/file/file.module
@@ -35,16 +35,6 @@
 
 // cspell:ignore abiword
 
-/**
- * The regex pattern used when checking for insecure file types.
- *
- * @deprecated in drupal:9.2.0 and is removed from drupal:10.0.0. Use
- *   \Drupal\Core\File\FileSystemInterface::INSECURE_EXTENSION_REGEX.
- *
- * @see https://www.drupal.org/node/3032541
- */
-define('FILE_INSECURE_EXTENSION_REGEX', FileSystemInterface::INSECURE_EXTENSION_REGEX);
-
 // Load all Field module hooks for File.
 require_once __DIR__ . '/file.field.inc';
 
@@ -723,252 +713,6 @@ function file_save_upload($form_field_name, $validators = [], $destination = FAL
   return isset($delta) ? $files[$delta] : $files;
 }
 
-/**
- * Saves a file upload to a new location.
- *
- * @param \SplFileInfo $file_info
- *   The file upload to save.
- * @param string $form_field_name
- *   A string that is the associative array key of the upload form element in
- *   the form array.
- * @param array $validators
- *   (optional) An associative array of callback functions used to validate the
- *   file.
- * @param bool $destination
- *   (optional) A string containing the URI that the file should be copied to.
- * @param int $replace
- *   (optional) The replace behavior when the destination file already exists.
- *
- * @return \Drupal\file\FileInterface|false
- *   The created file entity or FALSE if the uploaded file not saved.
- *
- * @throws \Drupal\Core\Entity\EntityStorageException
- *
- * @internal
- *   This method should only be called from file_save_upload(). Use that method
- *   instead.
- *
- * @deprecated in drupal:9.3.0 and is removed from drupal:10.0.0. Use
- *   \Drupal\file\Upload\FileUploadHandler::handleFileUpload() instead.
- *
- * @see https://www.drupal.org/node/3239547
- * @see file_save_upload()
- */
-function _file_save_upload_single(\SplFileInfo $file_info, $form_field_name, $validators = [], $destination = FALSE, $replace = FileSystemInterface::EXISTS_REPLACE) {
-  @trigger_error(__METHOD__ . '() is deprecated in drupal:9.3.0 and is removed from drupal:10.0.0. Use \Drupal\file\Upload\FileUploadHandler::handleFileUpload() instead. See https://www.drupal.org/node/3239547', E_USER_DEPRECATED);
-  $user = \Drupal::currentUser();
-  // Remember the original filename so we can print a message if it changes.
-  $original_file_name = $file_info->getClientOriginalName();
-  // Check for file upload errors and return FALSE for this file if a lower
-  // level system error occurred. For a complete list of errors:
-  // See http://php.net/manual/features.file-upload.errors.php.
-  switch ($file_info->getError()) {
-    case UPLOAD_ERR_INI_SIZE:
-    case UPLOAD_ERR_FORM_SIZE:
-      \Drupal::messenger()->addError(t('The file %file could not be saved because it exceeds %maxsize, the maximum allowed size for uploads.', ['%file' => $original_file_name, '%maxsize' => format_size(Environment::getUploadMaxSize())]));
-      return FALSE;
-
-    case UPLOAD_ERR_PARTIAL:
-    case UPLOAD_ERR_NO_FILE:
-      \Drupal::messenger()->addError(t('The file %file could not be saved because the upload did not complete.', ['%file' => $original_file_name]));
-      return FALSE;
-
-    case UPLOAD_ERR_OK:
-      // Final check that this is a valid upload, if it isn't, use the
-      // default error handler.
-      if (is_uploaded_file($file_info->getRealPath())) {
-        break;
-      }
-
-    default:
-      // Unknown error
-      \Drupal::messenger()->addError(t('The file %file could not be saved. An unknown error has occurred.', ['%file' => $original_file_name]));
-      return FALSE;
-
-  }
-
-  // Build a list of allowed extensions.
-  $extensions = '';
-  if (isset($validators['file_validate_extensions'])) {
-    if (isset($validators['file_validate_extensions'][0])) {
-      // Build the list of non-munged extensions if the caller provided them.
-      $extensions = $validators['file_validate_extensions'][0];
-    }
-    else {
-      // If 'file_validate_extensions' is set and the list is empty then the
-      // caller wants to allow any extension. In this case we have to remove the
-      // validator or else it will reject all extensions.
-      unset($validators['file_validate_extensions']);
-    }
-  }
-  else {
-    // No validator was provided, so add one using the default list.
-    // Build a default non-munged safe list for
-    // \Drupal\system\EventSubscriber\SecurityFileUploadEventSubscriber::sanitizeName().
-    $extensions = 'jpg jpeg gif png txt doc xls pdf ppt pps odt ods odp';
-    $validators['file_validate_extensions'] = [];
-    $validators['file_validate_extensions'][0] = $extensions;
-  }
-
-  // If the destination is not provided, use the temporary directory.
-  if (empty($destination)) {
-    $destination = 'temporary://';
-  }
-
-  /** @var \Drupal\Core\StreamWrapper\StreamWrapperManagerInterface $stream_wrapper_manager */
-  $stream_wrapper_manager = \Drupal::service('stream_wrapper_manager');
-
-  // Assert that the destination contains a valid stream.
-  $destination_scheme = $stream_wrapper_manager::getScheme($destination);
-  if (!$stream_wrapper_manager->isValidScheme($destination_scheme)) {
-    \Drupal::messenger()->addError(t('The file could not be uploaded because the destination %destination is invalid.', ['%destination' => $destination]));
-    return FALSE;
-  }
-
-  // A file URI may already have a trailing slash or look like "public://".
-  if (substr($destination, -1) != '/') {
-    $destination .= '/';
-  }
-
-  // Call an event to sanitize the filename and to attempt to address security
-  // issues caused by common server setups.
-  $event = new FileUploadSanitizeNameEvent($original_file_name, $extensions);
-  \Drupal::service('event_dispatcher')->dispatch($event);
-
-  // Begin building the file entity.
-  $values = [
-    'uid' => $user->id(),
-    'status' => 0,
-    // This will be replaced later with a filename based on the destination.
-    'filename' => $event->getFilename(),
-    'uri' => $file_info->getRealPath(),
-    'filesize' => $file_info->getSize(),
-  ];
-  $file = File::create($values);
-
-  /** @var \Drupal\Core\File\FileSystemInterface $file_system */
-  $file_system = \Drupal::service('file_system');
-  try {
-    // Use the result of the sanitization event as the destination name.
-    $file->destination = $file_system->getDestinationFilename($destination . $event->getFilename(), $replace);
-  }
-  catch (FileException $e) {
-    \Drupal::messenger()->addError(t('The file %filename could not be uploaded because the name is invalid.', ['%filename' => $file->getFilename()]));
-    return FALSE;
-  }
-
-  $guesser = \Drupal::service('file.mime_type.guesser');
-  $file->setMimeType($guesser->guessMimeType($values['filename']));
-  $file->source = $form_field_name;
-
-  // If the destination is FALSE then $replace === FILE_EXISTS_ERROR and
-  // there's an existing file, so we need to bail.
-  if ($file->destination === FALSE) {
-    \Drupal::messenger()->addError(t('The file %source could not be uploaded because a file by that name already exists in the destination %directory.', ['%source' => $form_field_name, '%directory' => $destination]));
-    return FALSE;
-  }
-
-  // Add in our check of the file name length.
-  $validators['file_validate_name_length'] = [];
-
-  // Call the validation functions specified by this function's caller.
-  $errors = file_validate($file, $validators);
-
-  // Check for errors.
-  if (!empty($errors)) {
-    $message = [
-      'error' => [
-        '#markup' => t('The specified file %name could not be uploaded.', ['%name' => $file->getFilename()]),
-      ],
-      'item_list' => [
-        '#theme' => 'item_list',
-        '#items' => $errors,
-      ],
-    ];
-    // @todo Add support for render arrays in
-    // \Drupal\Core\Messenger\MessengerInterface::addMessage()?
-    // @see https://www.drupal.org/node/2505497.
-    \Drupal::messenger()->addError(\Drupal::service('renderer')->renderPlain($message));
-    return FALSE;
-  }
-
-  $file->setFileUri($file->destination);
-  if (!$file_system->moveUploadedFile($file_info->getRealPath(), $file->getFileUri())) {
-    \Drupal::messenger()->addError(t('File upload error. Could not move uploaded file.'));
-    \Drupal::logger('file')->notice('Upload error. Could not move uploaded file %file to destination %destination.', ['%file' => $file->getFilename(), '%destination' => $file->getFileUri()]);
-    return FALSE;
-  }
-
-  // Update the filename with any changes as a result of the renaming due to an
-  // existing file.
-  $file->setFilename(\Drupal::service('file_system')->basename($file->destination));
-
-  // If the filename has been modified, let the user know.
-  if ($file->getFilename() !== $original_file_name) {
-    if ($event->isSecurityRename()) {
-      $message = t('For security reasons, your upload has been renamed to %filename.', ['%filename' => $file->getFilename()]);
-    }
-    else {
-      $message = t('Your upload has been renamed to %filename.', ['%filename' => $file->getFilename()]);
-    }
-    \Drupal::messenger()->addStatus($message);
-  }
-
-  // Set the permissions on the new file.
-  $file_system->chmod($file->getFileUri());
-
-  // If we are replacing an existing file re-use its database record.
-  // @todo Do not create a new entity in order to update it. See
-  //   https://www.drupal.org/node/2241865.
-  if ($replace == FileSystemInterface::EXISTS_REPLACE) {
-    $existing_files = \Drupal::entityTypeManager()->getStorage('file')->loadByProperties(['uri' => $file->getFileUri()]);
-    if (count($existing_files)) {
-      $existing = reset($existing_files);
-      $file->fid = $existing->id();
-      $file->setOriginalId($existing->id());
-    }
-  }
-
-  // Update the filename with any changes as a result of security or renaming
-  // due to an existing file.
-  $file->setFilename(\Drupal::service('file_system')->basename($file->destination));
-
-  // We can now validate the file object itself before it's saved.
-  $violations = $file->validate();
-  foreach ($violations as $violation) {
-    $errors[] = $violation->getMessage();
-  }
-  if (!empty($errors)) {
-    $message = [
-      'error' => [
-        '#markup' => t('The specified file %name could not be uploaded.', ['%name' => $file->getFilename()]),
-      ],
-      'item_list' => [
-        '#theme' => 'item_list',
-        '#items' => $errors,
-      ],
-    ];
-    // @todo Add support for render arrays in
-    // \Drupal\Core\Messenger\MessengerInterface::addMessage()?
-    // @see https://www.drupal.org/node/2505497.
-    \Drupal::messenger()->addError(\Drupal::service('renderer')->renderPlain($message));
-    return FALSE;
-  }
-
-  // If we made it this far it's safe to record this file in the database.
-  $file->save();
-
-  // Allow an anonymous user who creates a non-public file to see it. See
-  // \Drupal\file\FileAccessControlHandler::checkAccess().
-  if ($user->isAnonymous() && $destination_scheme !== 'public') {
-    $session = \Drupal::request()->getSession();
-    $allowed_temp_files = $session->get('anonymous_allowed_file_ids', []);
-    $allowed_temp_files[$file->id()] = $file->id();
-    $session->set('anonymous_allowed_file_ids', $allowed_temp_files);
-  }
-  return $file;
-}
-
 /**
  * Determines the preferred upload progress implementation.
  *