diff --git a/core/lib/Drupal/Core/Extension/InfoParserDynamic.php b/core/lib/Drupal/Core/Extension/InfoParserDynamic.php
index d54304cfc9..7257c48f4d 100644
--- a/core/lib/Drupal/Core/Extension/InfoParserDynamic.php
+++ b/core/lib/Drupal/Core/Extension/InfoParserDynamic.php
@@ -57,6 +57,11 @@ public function parse($filename) {
       if (!empty($missing_keys)) {
         throw new InfoParserException('Missing required keys (' . implode(', ', $missing_keys) . ') in ' . $filename);
       }
+      if ($parsed_info['type'] === 'profile' && isset($parsed_info['core_version_requirement'])) {
+        // @todo Support the 'core_version_requirement' key in profiles in
+        //   https://www.drupal.org/node/3070401.
+        throw new InfoParserException("The 'core_version_requirement' key is not supported in profiles in $filename");
+      }
       if (!isset($parsed_info['core']) && !isset($parsed_info['core_version_requirement'])) {
         throw new InfoParserException("The 'core' or the 'core_version_requirement' key must be present in " . $filename);
       }
diff --git a/core/tests/Drupal/Tests/Core/Extension/InfoParserUnitTest.php b/core/tests/Drupal/Tests/Core/Extension/InfoParserUnitTest.php
index 471d18e93f..45e2b975b4 100644
--- a/core/tests/Drupal/Tests/Core/Extension/InfoParserUnitTest.php
+++ b/core/tests/Drupal/Tests/Core/Extension/InfoParserUnitTest.php
@@ -442,4 +442,27 @@ public function providerCoreIncompatibility() {
     ];
   }
 
+  /**
+   * Test a profile info file with the 'core_version_requirement' key.
+   */
+  public function testInvalidProfile() {
+    $profile = <<<PROFILE_TEST
+core: 8.x
+core_version_requirement: ^8
+name: The Perfect Profile
+type: profile
+description: 'This profile makes Drupal perfect. You should have no complaints.'
+PROFILE_TEST;
+
+    vfsStream::setup('profiles');
+    vfsStream::create([
+      'fixtures' => [
+        'invalid_profile.info.txt' => $profile,
+      ],
+    ]);
+    $this->expectException('\Drupal\Core\Extension\InfoParserException');
+    $this->expectExceptionMessage("The 'core_version_requirement' key is not supported in profiles in vfs://profiles/fixtures/invalid_profile.info.txt");
+    $this->infoParser->parse(vfsStream::url('profiles/fixtures/invalid_profile.info.txt'));
+  }
+
 }