diff --git a/core/modules/layout_builder/css/layout-builder.css b/core/modules/layout_builder/css/layout-builder.css
index edb0c48cb7..2853da8b24 100644
--- a/core/modules/layout_builder/css/layout-builder.css
+++ b/core/modules/layout_builder/css/layout-builder.css
@@ -56,6 +56,10 @@
   padding: 1.5em;
 }
 
+.layout-section .layout-builder--layout__region .block [tabindex="-1"] {
+  pointer-events: none;
+}
+
 .layout-section .remove-section {
   position: relative;
   background: url(../../../misc/icons/bebebe/ex.svg) #fff center center / 16px 16px no-repeat;
diff --git a/core/modules/layout_builder/js/layout-builder.es6.js b/core/modules/layout_builder/js/layout-builder.es6.js
index f8f7b0be46..68eebcf4bf 100644
--- a/core/modules/layout_builder/js/layout-builder.es6.js
+++ b/core/modules/layout_builder/js/layout-builder.es6.js
@@ -1,5 +1,19 @@
-(($, { ajax, behaviors }) => {
-  behaviors.layoutBuilder = {
+/**
+ * @file
+ * Attaches the behaviors for the Layout Builder module.
+ */
+
+(($, Drupal) => {
+  const { ajax, behaviors } = Drupal;
+  /**
+   * Provides the ability to drag blocks to new positions in the layout.
+   *
+   * @type {Drupal~behavior}
+   *
+   * @prop {Drupal~behaviorAttach} attach
+   *   Attach block drag behavior to the Layout Builder UI.
+   */
+  behaviors.layoutBuilderBlockDrag = {
     attach(context) {
       $(context)
         .find('.layout-builder--layout__region')
@@ -51,4 +65,36 @@
         });
     },
   };
+  /**
+   * Disables interactive elements in previewed blocks.
+   *
+   * @type {Drupal~behavior}
+   *
+   * @prop {Drupal~behaviorAttach} attach
+   *   Attach disabling interactive elements behavior to the Layout Builder UI.
+   */
+  behaviors.layoutBuilderDisableInteractiveElements = {
+    attach(context) {
+      // Disable interactive elements inside preview blocks.
+      const $blocks = $('#layout-builder [data-layout-block-uuid]');
+      $blocks.find('input, textarea, select').prop('disabled', true);
+      $blocks.find('a').on('click mouseup touchstart', e => {
+        e.preventDefault();
+        e.stopPropagation();
+      });
+
+      /*
+       * In preview blocks, remove from the tabbing order all input elements
+       * and elements specifically assigned a tab index.
+       */
+      $blocks
+        .find(
+          'button, [href], input, select, textarea, iframe, [tabindex]:not([tabindex="-1"]):not(.tabbable)',
+        )
+        .attr('tabindex', -1);
+
+      // Don't allow links to be used as a sortable selection.
+      $('.layout-builder--layout__region').sortable({ cancel: 'a' });
+    },
+  };
 })(jQuery, Drupal);
diff --git a/core/modules/layout_builder/js/layout-builder.js b/core/modules/layout_builder/js/layout-builder.js
index 0f0de275ef..43a833fcd7 100644
--- a/core/modules/layout_builder/js/layout-builder.js
+++ b/core/modules/layout_builder/js/layout-builder.js
@@ -5,11 +5,11 @@
 * @preserve
 **/
 
-(function ($, _ref) {
-  var ajax = _ref.ajax,
-      behaviors = _ref.behaviors;
+(function ($, Drupal) {
+  var ajax = Drupal.ajax,
+      behaviors = Drupal.behaviors;
 
-  behaviors.layoutBuilder = {
+  behaviors.layoutBuilderBlockDrag = {
     attach: function attach(context) {
       $(context).find('.layout-builder--layout__region').sortable({
         items: '> .draggable',
@@ -32,4 +32,19 @@
       });
     }
   };
+
+  behaviors.layoutBuilderDisableInteractiveElements = {
+    attach: function attach(context) {
+      var $blocks = $('#layout-builder [data-layout-block-uuid]');
+      $blocks.find('input, textarea, select').prop('disabled', true);
+      $blocks.find('a').on('click mouseup touchstart', function (e) {
+        e.preventDefault();
+        e.stopPropagation();
+      });
+
+      $blocks.find('button, [href], input, select, textarea, iframe, [tabindex]:not([tabindex="-1"]):not(.tabbable)').attr('tabindex', -1);
+
+      $('.layout-builder--layout__region').sortable({ cancel: 'a' });
+    }
+  };
 })(jQuery, Drupal);
\ No newline at end of file
diff --git a/core/modules/layout_builder/layout_builder.module b/core/modules/layout_builder/layout_builder.module
index 71265e2d46..c5d5c5ded2 100644
--- a/core/modules/layout_builder/layout_builder.module
+++ b/core/modules/layout_builder/layout_builder.module
@@ -34,6 +34,7 @@ function layout_builder_help($route_name, RouteMatchInterface $route_match) {
     else {
       $output .= '<p>' . t('To manage other areas of the page, use the block administration page.') . '</p>';
     }
+    $output .= '<p>' . t('Forms and links inside the content of the layout builder tool have been disabled.') . '</p>';
     return $output;
   }
 
diff --git a/core/modules/layout_builder/tests/src/FunctionalJavascript/LayoutBuilderDisableInteractionsTest.php b/core/modules/layout_builder/tests/src/FunctionalJavascript/LayoutBuilderDisableInteractionsTest.php
new file mode 100644
index 0000000000..62bc312293
--- /dev/null
+++ b/core/modules/layout_builder/tests/src/FunctionalJavascript/LayoutBuilderDisableInteractionsTest.php
@@ -0,0 +1,186 @@
+<?php
+
+namespace Drupal\Tests\layout_builder\FunctionalJavascript;
+
+use Behat\Mink\Element\NodeElement;
+use Drupal\block_content\Entity\BlockContent;
+use Drupal\block_content\Entity\BlockContentType;
+use Drupal\Component\Render\FormattableMarkup;
+use Drupal\FunctionalJavascriptTests\WebDriverTestBase;
+use WebDriver\Exception\UnknownError;
+
+/**
+ * Tests the Layout Builder disables interactions of rendered blocks.
+ *
+ * @group layout_builder
+ */
+class LayoutBuilderDisableInteractionsTest extends WebDriverTestBase {
+
+  /**
+   * {@inheritdoc}
+   */
+  protected static $modules = [
+    'block',
+    'block_content',
+    'filter',
+    'filter_test',
+    'layout_builder',
+    'node',
+    'search',
+  ];
+
+  /**
+   * {@inheritdoc}
+   */
+  protected function setUp() {
+    parent::setUp();
+
+    // @todo The Layout Builder UI relies on local tasks; fix in
+    //   https://www.drupal.org/project/drupal/issues/2917777.
+    $this->drupalPlaceBlock('local_tasks_block');
+
+    $this->createContentType(['type' => 'bundle_with_section_field']);
+    $this->createNode([
+      'type' => 'bundle_with_section_field',
+      'title' => 'The first node title',
+      'body' => [
+        [
+          'value' => 'Node body',
+        ],
+      ],
+    ]);
+
+    $bundle = BlockContentType::create([
+      'id' => 'basic',
+      'label' => 'Basic block',
+      'revision' => 1,
+    ]);
+    $bundle->save();
+    block_content_add_body_field($bundle->id());
+
+    BlockContent::create([
+      'type' => 'basic',
+      'info' => 'Block with link',
+      'body' => [
+        // Create a link that should be disabled in Layout Builder preview.
+        'value' => '<a id="link-that-should-be-disabled" href="/search/node">Take me away</a>',
+        'format' => 'full_html',
+      ],
+    ])->save();
+
+    BlockContent::create([
+      'type' => 'basic',
+      'info' => 'Block with iframe',
+      'body' => [
+        // Add iframe that should be non-interactive in Layout Builder preview.
+        'value' => '<iframe id="iframe-that-should-be-disabled" width="560" height="315" src="https://www.youtube.com/embed/gODZzSOelss" frameborder="0"></iframe>',
+        'format' => 'full_html',
+      ],
+    ])->save();
+  }
+
+  /**
+   * Tests that forms and links are disabled in the Layout Builder preview.
+   */
+  public function testFormsLinksDisabled() {
+    $assert_session = $this->assertSession();
+
+    $this->drupalLogin($this->drupalCreateUser([
+      'configure any layout',
+      'administer node display',
+      'administer node fields',
+      'search content',
+    ]));
+
+    $field_ui_prefix = 'admin/structure/types/manage/bundle_with_section_field';
+
+    $this->drupalPostForm("$field_ui_prefix/display", ['layout[enabled]' => TRUE], 'Save');
+    $assert_session->linkExists('Manage layout');
+    $this->clickLink('Manage layout');
+
+    $this->drupalGet("$field_ui_prefix/display-layout/default");
+
+    // Add a block with a form, another with a link, and one with an iframe.
+    $this->addBlock('Search form', '#layout-builder .search-block-form');
+    $this->drupalGet("$field_ui_prefix/display-layout/default");
+    $this->addBlock('Block with link', '#link-that-should-be-disabled');
+    $this->drupalGet("$field_ui_prefix/display-layout/default");
+    $this->addBlock('Block with iframe', '#iframe-that-should-be-disabled');
+
+    // Ensure the links and forms are disabled using the defaults before the
+    // layout is saved.
+    $this->assertLinksFormIframeNotInteractive();
+    $this->clickLink('Save Layout');
+    $this->clickLink('Manage layout');
+
+    // Ensure the links and forms are disabled using the defaults.
+    $this->assertLinksFormIframeNotInteractive();
+
+    $this->drupalPostForm("$field_ui_prefix/display/default", ['layout[allow_custom]' => TRUE], 'Save');
+    $this->drupalGet('node/1/layout');
+
+    // Ensure the links and forms are also disabled in using the override.
+    $this->assertLinksFormIframeNotInteractive();
+  }
+
+  /**
+   * Adds a block in the Layout Builder.
+   *
+   * @param string $block_link_text
+   *   The link text to add the block.
+   * @param string $rendered_locator
+   *   The CSS locator to confirm the block was rendered.
+   */
+  protected function addBlock($block_link_text, $rendered_locator) {
+    $assert_session = $this->assertSession();
+    $page = $this->getSession()->getPage();
+    // Add a new block.
+    $this->assertNotEmpty($assert_session->waitForElementVisible('css', '#layout-builder a:contains(\'Add Block\')'));
+    $this->clickLink('Add Block');
+    $this->assertNotEmpty($assert_session->waitForElementVisible('css', '#drupal-off-canvas'));
+    $assert_session->assertWaitOnAjaxRequest();
+
+    $assert_session->linkExists($block_link_text);
+    $this->clickLink($block_link_text);
+    // Wait for off-canvas dialog to reopen with block form.
+    $this->assertNotEmpty($assert_session->waitForElementVisible('css', ".layout-builder-add-block"));
+    $assert_session->assertWaitOnAjaxRequest();
+    $page->pressButton('Add Block');
+
+    // Wait for block form to be rendered in the Layout Builder.
+    $this->assertNotEmpty($assert_session->waitForElement('css', $rendered_locator));
+  }
+
+  /**
+   * Checks if element is unclickable.
+   *
+   * @param \Behat\Mink\Element\NodeElement $element
+   *   Element being checked for.
+   */
+  protected function assertElementUnclickable(NodeElement $element) {
+    try {
+      $element->click();
+      $tag_name = $element->getTagName();
+      $this->fail(new FormattableMarkup("@tag_name was clickable when it shouldn't have been", ['@tag_name' => $tag_name]));
+    }
+    catch (UnknownError $e) {
+      $this->assertContains('is not clickable at point', $e->getMessage());
+    }
+  }
+
+  /**
+   * Asserts that forms, links, and iframes in preview are non-interactive.
+   */
+  protected function assertLinksFormIframeNotInteractive() {
+    $assert_session = $this->assertSession();
+    $page = $this->getSession()->getPage();
+    $this->assertNotEmpty($assert_session->waitForElement('css', '#layout-builder .search-block-form'));
+    $searchButton = $assert_session->buttonExists('Search');
+    $this->assertElementUnclickable($searchButton);
+    $assert_session->linkExists('Take me away');
+    $this->assertElementUnclickable($page->findLink('Take me away'));
+    $iframe = $assert_session->elementExists('css', '#iframe-that-should-be-disabled');
+    $this->assertElementUnclickable($iframe);
+  }
+
+}