diff --git a/core/core.services.yml b/core/core.services.yml
index 92b2280fb2..8c265c4deb 100644
--- a/core/core.services.yml
+++ b/core/core.services.yml
@@ -304,7 +304,7 @@ services:
       - { name: event_subscriber }
   config.installer:
     class: Drupal\Core\Config\ConfigInstaller
-    arguments: ['@config.factory', '@config.storage', '@config.typed', '@config.manager', '@event_dispatcher', '%install_profile%']
+    arguments: ['@config.factory', '@config.storage', '@config.typed', '@config.manager', '@event_dispatcher', '%install_profile%', '@profile_handler']
     lazy: true
   config.storage:
     class: Drupal\Core\Config\CachedStorage
@@ -517,6 +517,9 @@ services:
       - { name: module_install.uninstall_validator }
     arguments: ['@string_translation']
     lazy: true
+  profile_handler:
+    class: Drupal\Core\Extension\ProfileHandler
+    arguments: ['@app.root', '@info_parser']
   theme_handler:
     class: Drupal\Core\Extension\ThemeHandler
     arguments: ['@app.root', '@config.factory', '@module_handler', '@state', '@info_parser']
diff --git a/core/includes/install.core.inc b/core/includes/install.core.inc
index 2882e37492..5f498511d5 100644
--- a/core/includes/install.core.inc
+++ b/core/includes/install.core.inc
@@ -452,6 +452,12 @@ function install_begin_request($class_loader, &$install_state) {
     if (isset($install_state['profile_info']['distribution']['install']['theme'])) {
       $install_state['theme'] = $install_state['profile_info']['distribution']['install']['theme'];
     }
+    // Ensure all profile directories are registered.
+    $profiles = \Drupal::service('profile_handler')->getProfileInheritance($profile);
+    $profile_directories = array_map(function ($extension) {
+      return $extension->getPath();
+    }, $profiles);
+    $listing->setProfileDirectories($profile_directories);
   }
 
   // Use the language from the profile configuration, if available, to override
@@ -1215,6 +1221,8 @@ function install_select_profile(&$install_state) {
  *   - For non-interactive installations via install_drupal() settings.
  * - A discovered profile that is a distribution. If multiple profiles are
  *   distributions, then the first discovered profile will be selected.
+ *   If an inherited profile is detected that is a distribution, it will be
+ *   chosen over its base profile.
  * - Only one visible profile is available.
  *
  * @param array $install_state
@@ -1237,11 +1245,8 @@ function _install_select_profile(&$install_state) {
     }
   }
   // Check for a distribution profile.
-  foreach ($install_state['profiles'] as $profile) {
-    $profile_info = install_profile_info($profile->getName());
-    if (!empty($profile_info['distribution'])) {
-      return $profile->getName();
-    }
+  if ($distribution = \Drupal::service('profile_handler')->selectDistribution(array_keys($install_state['profiles']))) {
+    return $distribution;
   }
 
   // Get all visible (not hidden) profiles.
@@ -1574,7 +1579,10 @@ function install_profile_themes(&$install_state) {
  *   An array of information about the current installation state.
  */
 function install_install_profile(&$install_state) {
-  \Drupal::service('module_installer')->install([drupal_get_profile()], FALSE);
+  // Install all the profiles.
+  $profiles = \Drupal::service('profile_handler')->getProfileInheritance();
+  \Drupal::service('module_installer')->install(array_keys($profiles), FALSE);
+
   // Install all available optional config. During installation the module order
   // is determined by dependencies. If there are no dependencies between modules
   // then the order in which they are installed is dependent on random factors
diff --git a/core/includes/install.inc b/core/includes/install.inc
index 3529d51a98..3462250e81 100644
--- a/core/includes/install.inc
+++ b/core/includes/install.inc
@@ -1047,6 +1047,14 @@ function drupal_check_module($module) {
  *   - install: Optional parameters to override the installer:
  *     - theme: The machine name of a theme to use in the installer instead of
  *       Drupal's default installer theme.
+ * - base profile: Existence of this key denotes that the installation profile
+ *   depends on a parent installation profile.
+ *   - name: The shortname of the base installation profile.
+ *   - excluded_dependencies: An array of shortnames of other modules that have
+ *     to be excluded from the base profile requirements. This allows e.g. to
+ *     disable a demo module that would be installed by the base profile.
+ *   If there are no excluded_dependencies, a shortcut of "base profile: name"
+ *   can be used.
  *
  * Note that this function does an expensive file system scan to get info file
  * information for dependencies. If you only need information from the info
@@ -1073,18 +1081,7 @@ function install_profile_info($profile, $langcode = 'en') {
   $cache = &drupal_static(__FUNCTION__, []);
 
   if (!isset($cache[$profile][$langcode])) {
-    // Set defaults for module info.
-    $defaults = [
-      'dependencies' => [],
-      'themes' => ['stark'],
-      'description' => '',
-      'version' => NULL,
-      'hidden' => FALSE,
-      'php' => DRUPAL_MINIMUM_PHP,
-    ];
-    $profile_file = drupal_get_path('profile', $profile) . "/$profile.info.yml";
-    $info = \Drupal::service('info_parser')->parse($profile_file);
-    $info += $defaults;
+    $info = \Drupal::service('profile_handler')->getProfileInfo($profile);
 
     // drupal_required_modules() includes the current profile as a dependency.
     // Remove that dependency, since a module cannot depend on itself.
diff --git a/core/lib/Drupal/Core/Config/ConfigInstaller.php b/core/lib/Drupal/Core/Config/ConfigInstaller.php
index 242d92097e..134a34c535 100644
--- a/core/lib/Drupal/Core/Config/ConfigInstaller.php
+++ b/core/lib/Drupal/Core/Config/ConfigInstaller.php
@@ -6,6 +6,7 @@
 use Drupal\Component\Utility\Unicode;
 use Drupal\Core\Config\Entity\ConfigDependencyManager;
 use Drupal\Core\Config\Entity\ConfigEntityDependency;
+use Drupal\Core\Extension\ProfileHandlerInterface;
 use Symfony\Component\EventDispatcher\EventDispatcherInterface;
 
 class ConfigInstaller implements ConfigInstallerInterface {
@@ -52,6 +53,13 @@ class ConfigInstaller implements ConfigInstallerInterface {
    */
   protected $sourceStorage;
 
+  /**
+   * The profile handler.
+   *
+   * @var \Drupal\Core\Extension\ProfileHandlerInterface
+   */
+  protected $profileHandler;
+
   /**
    * Is configuration being created as part of a configuration sync.
    *
@@ -81,14 +89,17 @@ class ConfigInstaller implements ConfigInstallerInterface {
    *   The event dispatcher.
    * @param string $install_profile
    *   The name of the currently active installation profile.
+   * @param \Drupal\Core\Extension\ProfileHandlerInterface $profile_handler
+   *   (optional) The profile handler.
    */
-  public function __construct(ConfigFactoryInterface $config_factory, StorageInterface $active_storage, TypedConfigManagerInterface $typed_config, ConfigManagerInterface $config_manager, EventDispatcherInterface $event_dispatcher, $install_profile) {
+  public function __construct(ConfigFactoryInterface $config_factory, StorageInterface $active_storage, TypedConfigManagerInterface $typed_config, ConfigManagerInterface $config_manager, EventDispatcherInterface $event_dispatcher, $install_profile, ProfileHandlerInterface $profile_handler = NULL) {
     $this->configFactory = $config_factory;
     $this->activeStorages[$active_storage->getCollectionName()] = $active_storage;
     $this->typedConfig = $typed_config;
     $this->configManager = $config_manager;
     $this->eventDispatcher = $event_dispatcher;
     $this->installProfile = $install_profile;
+    $this->profileHandler = $profile_handler ?: \Drupal::service('profile_handler');
   }
 
   /**
@@ -471,7 +482,8 @@ public function checkConfigurationToInstall($type, $name) {
 
     // Install profiles can not have config clashes. Configuration that
     // has the same name as a module's configuration will be used instead.
-    if ($name != $this->drupalGetProfile()) {
+    $profiles = $this->profileHandler->getProfileInheritance();
+    if (!isset($profiles[$name])) {
       // Throw an exception if the module being installed contains configuration
       // that already exists. Additionally, can not continue installing more
       // modules because those may depend on the current module being installed.
diff --git a/core/lib/Drupal/Core/Config/ExtensionInstallStorage.php b/core/lib/Drupal/Core/Config/ExtensionInstallStorage.php
index 9103ab8c07..c3a026b5a4 100644
--- a/core/lib/Drupal/Core/Config/ExtensionInstallStorage.php
+++ b/core/lib/Drupal/Core/Config/ExtensionInstallStorage.php
@@ -3,6 +3,7 @@
 namespace Drupal\Core\Config;
 
 use Drupal\Core\Extension\ExtensionDiscovery;
+use Drupal\Core\Extension\ProfileHandlerInterface;
 
 /**
  * Storage to access configuration and schema in enabled extensions.
@@ -52,9 +53,11 @@ class ExtensionInstallStorage extends InstallStorage {
    *   (optional) The current installation profile. This parameter will be
    *   mandatory in Drupal 9.0.0. In Drupal 8.3.0 not providing this parameter
    *   will trigger a silenced deprecation warning.
+   * @param \Drupal\Core\Extension\ProfileHandlerInterface $profile_handler
+   *   (optional) The profile handler.
    */
-  public function __construct(StorageInterface $config_storage, $directory = self::CONFIG_INSTALL_DIRECTORY, $collection = StorageInterface::DEFAULT_COLLECTION, $include_profile = TRUE, $profile = NULL) {
-    parent::__construct($directory, $collection);
+  public function __construct(StorageInterface $config_storage, $directory = self::CONFIG_INSTALL_DIRECTORY, $collection = StorageInterface::DEFAULT_COLLECTION, $include_profile = TRUE, $profile = NULL, ProfileHandlerInterface $profile_handler = NULL) {
+    parent::__construct($directory, $collection, $profile_handler);
     $this->configStorage = $config_storage;
     $this->includeProfile = $include_profile;
     if (is_null($profile)) {
@@ -93,19 +96,11 @@ protected function getAllFolders() {
 
       $extensions = $this->configStorage->read('core.extension');
       // @todo Remove this scan as part of https://www.drupal.org/node/2186491
-      $listing = new ExtensionDiscovery(\Drupal::root());
+      $listing = new ExtensionDiscovery(\Drupal::root(), TRUE, NULL, NULL, $this->profileHandler);
       if (!empty($extensions['module'])) {
         $modules = $extensions['module'];
         // Remove the install profile as this is handled later.
         unset($modules[$this->installProfile]);
-        $profile_list = $listing->scan('profile');
-        if ($this->installProfile && isset($profile_list[$this->installProfile])) {
-          // Prime the drupal_get_filename() static cache with the profile info
-          // file location so we can use drupal_get_path() on the active profile
-          // during the module scan.
-          // @todo Remove as part of https://www.drupal.org/node/2186491
-          drupal_get_filename('profile', $this->installProfile, $profile_list[$this->installProfile]->getPathname());
-        }
         $module_list_scan = $listing->scan('module');
         $module_list = [];
         foreach (array_keys($modules) as $module) {
@@ -126,18 +121,11 @@ protected function getAllFolders() {
       }
 
       if ($this->includeProfile) {
-        // The install profile can override module default configuration. We do
-        // this by replacing the config file path from the module/theme with the
-        // install profile version if there are any duplicates.
-        if ($this->installProfile) {
-          if (!isset($profile_list)) {
-            $profile_list = $listing->scan('profile');
-          }
-          if (isset($profile_list[$this->installProfile])) {
-            $profile_folders = $this->getComponentNames([$profile_list[$this->installProfile]]);
-            $this->folders = $profile_folders + $this->folders;
-          }
-        }
+        // The install profile (and any parent profiles) can override module
+        // default configuration. We do this by replacing the config file path
+        // from the module/theme with the install profile version if there are
+        // any duplicates.
+        $this->folders += $this->getComponentNames($this->profileHandler->getProfileInheritance($this->installProfile));
       }
     }
     return $this->folders;
diff --git a/core/lib/Drupal/Core/Config/InstallStorage.php b/core/lib/Drupal/Core/Config/InstallStorage.php
index c8d189e480..01fb7b6a0f 100644
--- a/core/lib/Drupal/Core/Config/InstallStorage.php
+++ b/core/lib/Drupal/Core/Config/InstallStorage.php
@@ -4,6 +4,7 @@
 
 use Drupal\Core\Extension\ExtensionDiscovery;
 use Drupal\Core\Extension\Extension;
+use Drupal\Core\Extension\ProfileHandlerInterface;
 
 /**
  * Storage used by the Drupal installer.
@@ -47,6 +48,13 @@ class InstallStorage extends FileStorage {
    */
   protected $directory;
 
+  /**
+   * The profile handler used to find additional folders to scan for config.
+   *
+   * @var \Drupal\Core\Extension\ProfileHandlerInterface
+   */
+  protected $profileHandler;
+
   /**
    * Constructs an InstallStorage object.
    *
@@ -56,9 +64,14 @@ class InstallStorage extends FileStorage {
    * @param string $collection
    *   (optional) The collection to store configuration in. Defaults to the
    *   default collection.
+   * @param \Drupal\Core\Extension\ProfileHandlerInterface $profile_handler
+   *   (optional) The profile handler.
    */
-  public function __construct($directory = self::CONFIG_INSTALL_DIRECTORY, $collection = StorageInterface::DEFAULT_COLLECTION) {
+  public function __construct($directory = self::CONFIG_INSTALL_DIRECTORY, $collection = StorageInterface::DEFAULT_COLLECTION, ProfileHandlerInterface $profile_handler = NULL) {
     parent::__construct($directory, $collection);
+    if (\Drupal::hasService('profile_handler')) {
+      $this->profileHandler = $profile_handler ?: \Drupal::service('profile_handler');
+    }
   }
 
   /**
@@ -151,21 +164,12 @@ protected function getAllFolders() {
     if (!isset($this->folders)) {
       $this->folders = [];
       $this->folders += $this->getCoreNames();
+      // Get dependent profiles and add the extension components.
+      $this->folders += $this->getComponentNames($this->profileHandler->getProfileInheritance());
       // Perform an ExtensionDiscovery scan as we cannot use drupal_get_path()
       // yet because the system module may not yet be enabled during install.
       // @todo Remove as part of https://www.drupal.org/node/2186491
       $listing = new ExtensionDiscovery(\Drupal::root());
-      if ($profile = drupal_get_profile()) {
-        $profile_list = $listing->scan('profile');
-        if (isset($profile_list[$profile])) {
-          // Prime the drupal_get_filename() static cache with the profile info
-          // file location so we can use drupal_get_path() on the active profile
-          // during the module scan.
-          // @todo Remove as part of https://www.drupal.org/node/2186491
-          drupal_get_filename('profile', $profile, $profile_list[$profile]->getPathname());
-          $this->folders += $this->getComponentNames([$profile_list[$profile]]);
-        }
-      }
       // @todo Remove as part of https://www.drupal.org/node/2186491
       $this->folders += $this->getComponentNames($listing->scan('module'));
       $this->folders += $this->getComponentNames($listing->scan('theme'));
diff --git a/core/lib/Drupal/Core/EventSubscriber/ConfigImportSubscriber.php b/core/lib/Drupal/Core/EventSubscriber/ConfigImportSubscriber.php
index ea7d29fedf..19171af224 100644
--- a/core/lib/Drupal/Core/EventSubscriber/ConfigImportSubscriber.php
+++ b/core/lib/Drupal/Core/EventSubscriber/ConfigImportSubscriber.php
@@ -2,6 +2,7 @@
 
 namespace Drupal\Core\EventSubscriber;
 
+use Drupal\core\Extension\Extension;
 use Drupal\Core\Config\Config;
 use Drupal\Core\Config\ConfigImporter;
 use Drupal\Core\Config\ConfigImporterEvent;
@@ -91,12 +92,18 @@ protected function validateModules(ConfigImporter $config_importer) {
       $config_importer->logError($this->t('Unable to install the %module module since it does not exist.', ['%module' => $module]));
     }
 
+    // Get a list of parent profiles and the main profile.
+    /* @var $profiles \Drupal\Core\Extension\Extension[] */
+    $profiles = \Drupal::service('profile_handler')->getProfileInheritance();
+    /* @var $main_profile \Drupal\Core\Extension\Extension */
+    $main_profile = end($profiles);
+
     // Ensure that all modules being installed have their dependencies met.
     $installs = $config_importer->getExtensionChangelist('module', 'install');
     foreach ($installs as $module) {
       $missing_dependencies = [];
       foreach (array_keys($module_data[$module]->requires) as $required_module) {
-        if (!isset($core_extension['module'][$required_module])) {
+        if (!isset($core_extension['module'][$required_module]) && !array_key_exists($module, $profiles)) {
           $missing_dependencies[] = $module_data[$required_module]->info['name'];
         }
       }
@@ -111,32 +118,59 @@ protected function validateModules(ConfigImporter $config_importer) {
       }
     }
 
-    // Get the install profile from the site's configuration.
+    // Get the active install profile from the site's configuration.
     $current_core_extension = $config_importer->getStorageComparer()->getTargetStorage()->read('core.extension');
-    $install_profile = isset($current_core_extension['profile']) ? $current_core_extension['profile'] : NULL;
+    if (isset($current_core_extension['profile'])) {
+      // Ensure the active profile is not changing.
+      if ($current_core_extension['profile'] !== $core_extension['profile']) {
+        $config_importer->logError($this->t('Cannot change the install profile from %new_profile to %profile once Drupal is installed.', ['%profile' => $current_core_extension['profile'], '%new_profile' => $core_extension['profile']]));
+      }
+    }
 
     // Ensure that all modules being uninstalled are not required by modules
     // that will be installed after the import.
     $uninstalls = $config_importer->getExtensionChangelist('module', 'uninstall');
     foreach ($uninstalls as $module) {
       foreach (array_keys($module_data[$module]->required_by) as $dependent_module) {
-        if ($module_data[$dependent_module]->status && !in_array($dependent_module, $uninstalls, TRUE) && $dependent_module !== $install_profile) {
-          $module_name = $module_data[$module]->info['name'];
-          $dependent_module_name = $module_data[$dependent_module]->info['name'];
-          $config_importer->logError($this->t('Unable to uninstall the %module module since the %dependent_module module is installed.', ['%module' => $module_name, '%dependent_module' => $dependent_module_name]));
+        if ($module_data[$dependent_module]->status && !in_array($dependent_module, $uninstalls, TRUE)) {
+          if (!array_key_exists($dependent_module, $profiles)) {
+            $module_name = $module_data[$module]->info['name'];
+            $dependent_module_name = $module_data[$dependent_module]->info['name'];
+            $config_importer->logError($this->t('Unable to uninstall the %module module since the %dependent_module module is installed.', [
+              '%module' => $module_name,
+              '%dependent_module' => $dependent_module_name
+            ]));
+          }
         }
       }
     }
 
-    // Ensure that the install profile is not being uninstalled.
-    if (in_array($install_profile, $uninstalls, TRUE)) {
-      $profile_name = $module_data[$install_profile]->info['name'];
-      $config_importer->logError($this->t('Unable to uninstall the %profile profile since it is the install profile.', ['%profile' => $profile_name]));
-    }
+    // Don't allow profiles to be uninstalled. It's possible for no profile to
+    // be set yet if the config is being imported during initial site install.
+    if ($main_profile instanceof Extension) {
+      if (in_array($main_profile->getName(), $uninstalls, TRUE)) {
+        // Ensure that the active profile is not being uninstalled.
+        $profile_name = $main_profile->info['name'];
+        $config_importer->logError($this->t('Unable to uninstall the %profile profile since it is the main install profile.', ['%profile' => $profile_name]));
+      }
 
-    // Ensure the profile is not changing.
-    if ($install_profile !== $core_extension['profile']) {
-      $config_importer->logError($this->t('Cannot change the install profile from %profile to %new_profile once Drupal is installed.', ['%profile' => $install_profile, '%new_profile' => $core_extension['profile']]));
+      if ($profile_uninstalls = array_intersect_key($profiles, array_flip($uninstalls))) {
+        // Ensure that none of the parent profiles are being uninstalled.
+        $profile_names = [];
+        foreach ($profile_uninstalls as $profile) {
+          if ($profile->getName() !== $main_profile->getName()) {
+            $profile_names[] = $module_data[$profile->getName()]->info['name'];
+          }
+        }
+        if (!empty($profile_names)) {
+          $message = $this->formatPlural(count($profile_names),
+            'Unable to uninstall the :profile profile since it is a parent of another installed profile.',
+            'Unable to uninstall the :profile profiles since they are parents of another installed profile.',
+            [':profile' => implode(', ', $profile_names)]
+          );
+          $config_importer->logError($message);
+        }
+      }
     }
   }
 
diff --git a/core/lib/Drupal/Core/Extension/ExtensionDiscovery.php b/core/lib/Drupal/Core/Extension/ExtensionDiscovery.php
index 17c0e5b4a3..57b7fbfd6e 100644
--- a/core/lib/Drupal/Core/Extension/ExtensionDiscovery.php
+++ b/core/lib/Drupal/Core/Extension/ExtensionDiscovery.php
@@ -91,6 +91,15 @@ class ExtensionDiscovery {
    */
   protected $sitePath;
 
+  /**
+   * The profile handler.
+   *
+   * Used to determine the directories in which we want to scan for modules.
+   *
+   * @var \Drupal\Core\Extension\ProfileHandlerInterface|null
+   */
+  protected $profileHandler;
+
   /**
    * Constructs a new ExtensionDiscovery object.
    *
@@ -102,12 +111,27 @@ class ExtensionDiscovery {
    *   The available profile directories
    * @param string $site_path
    *   The path to the site.
+   * @param \Drupal\Core\Extension\ProfileHandlerInterface $profile_handler
+   *   (optional) The profile handler.
    */
-  public function __construct($root, $use_file_cache = TRUE, $profile_directories = NULL, $site_path = NULL) {
+  public function __construct($root, $use_file_cache = TRUE, $profile_directories = NULL, $site_path = NULL, ProfileHandlerInterface $profile_handler = NULL) {
     $this->root = $root;
     $this->fileCache = $use_file_cache ? FileCacheFactory::get('extension_discovery') : NULL;
     $this->profileDirectories = $profile_directories;
     $this->sitePath = $site_path;
+
+    // ExtensionDiscovery can be used without a service container
+    // (@drupalKernel::moduleData), so create a fallback profile handler if the
+    // profile_handler service is unavailable.
+    if ($profile_handler) {
+      $this->profileHandler = $profile_handler;
+    }
+    elseif (\Drupal::hasService('profile_handler')) {
+      $this->profileHandler = \Drupal::service('profile_handler');
+    }
+    else {
+      $this->profileHandler = new FallbackProfileHandler($root);
+    }
   }
 
   /**
@@ -241,7 +265,11 @@ public function setProfileDirectoriesFromSettings() {
     // In case both profile directories contain the same extension, the actual
     // profile always has precedence.
     if ($profile) {
-      $this->profileDirectories[] = drupal_get_path('profile', $profile);
+      $profiles = $this->profileHandler->getProfileInheritance($profile);
+      $profile_directories = array_map(function ($extension) {
+        return $extension->getPath();
+      }, $profiles);
+      $this->profileDirectories = array_unique(array_merge($profile_directories, $this->profileDirectories));
     }
     return $this;
   }
diff --git a/core/lib/Drupal/Core/Extension/ModuleInstaller.php b/core/lib/Drupal/Core/Extension/ModuleInstaller.php
index 5e9a4933be..3e20f0e4ca 100644
--- a/core/lib/Drupal/Core/Extension/ModuleInstaller.php
+++ b/core/lib/Drupal/Core/Extension/ModuleInstaller.php
@@ -345,7 +345,7 @@ public function uninstall(array $module_list, $uninstall_dependents = TRUE) {
     if ($uninstall_dependents) {
       // Add dependent modules to the list. The new modules will be processed as
       // the foreach loop continues.
-      $profile = drupal_get_profile();
+      $profiles = \Drupal::service('profile_handler')->getProfileInheritance();
       foreach ($module_list as $module => $value) {
         foreach (array_keys($module_data[$module]->required_by) as $dependent) {
           if (!isset($module_data[$dependent])) {
@@ -353,8 +353,8 @@ public function uninstall(array $module_list, $uninstall_dependents = TRUE) {
             return FALSE;
           }
 
-          // Skip already uninstalled modules.
-          if (isset($installed_modules[$dependent]) && !isset($module_list[$dependent]) && $dependent != $profile) {
+          // Skip already uninstalled modules and dependencies of profiles.
+          if (isset($installed_modules[$dependent]) && !isset($module_list[$dependent]) && (!array_key_exists($dependent, $profiles))) {
             $module_list[$dependent] = $dependent;
           }
         }
diff --git a/core/modules/config/tests/src/Functional/ConfigImportInstallProfileTest.php b/core/modules/config/tests/src/Functional/ConfigImportInstallProfileTest.php
index 8b0787d6ee..d8d33da0e6 100644
--- a/core/modules/config/tests/src/Functional/ConfigImportInstallProfileTest.php
+++ b/core/modules/config/tests/src/Functional/ConfigImportInstallProfileTest.php
@@ -56,7 +56,7 @@ public function testInstallProfileValidation() {
 
     $this->drupalPostForm('admin/config/development/configuration', [], t('Import all'));
     $this->assertText('The configuration cannot be imported because it failed validation for the following reasons:');
-    $this->assertText('Unable to uninstall the Testing config import profile since it is the install profile.');
+    $this->assertText('Unable to uninstall the Testing config import profile since it is the main install profile.');
 
     // Uninstall dependencies of testing_config_import.
     $core['module']['testing_config_import'] = 0;
diff --git a/core/modules/system/src/Form/ModulesUninstallForm.php b/core/modules/system/src/Form/ModulesUninstallForm.php
index 7949067925..cd77c20b29 100644
--- a/core/modules/system/src/Form/ModulesUninstallForm.php
+++ b/core/modules/system/src/Form/ModulesUninstallForm.php
@@ -116,12 +116,15 @@ public function buildForm(array $form, FormStateInterface $form_state) {
       return $form;
     }
 
-    $profile = drupal_get_profile();
+    $profiles = \Drupal::service('profile_handler')->getProfileInheritance();
 
     // Sort all modules by their name.
     uasort($uninstallable, 'system_sort_modules_by_info_name');
     $validation_reasons = $this->moduleInstaller->validateUninstall(array_keys($uninstallable));
 
+    // Remove any profiles from the list.
+    $uninstallable = array_diff_key($uninstallable, $profiles);
+
     $form['uninstall'] = ['#tree' => TRUE];
     foreach ($uninstallable as $module_key => $module) {
       $name = $module->info['name'] ?: $module->getName();
@@ -142,10 +145,10 @@ public function buildForm(array $form, FormStateInterface $form_state) {
         $form['uninstall'][$module->getName()]['#disabled'] = TRUE;
       }
       // All modules which depend on this one must be uninstalled first, before
-      // we can allow this module to be uninstalled. (The installation profile
-      // is excluded from this list.)
+      // we can allow this module to be uninstalled. (Installation profiles are
+      // excluded from this list.)
       foreach (array_keys($module->required_by) as $dependent) {
-        if ($dependent != $profile && drupal_get_installed_schema_version($dependent) != SCHEMA_UNINSTALLED) {
+        if (!in_array($dependent, array_keys($profiles)) && drupal_get_installed_schema_version($dependent) != SCHEMA_UNINSTALLED) {
           $name = isset($modules[$dependent]->info['name']) ? $modules[$dependent]->info['name'] : $dependent;
           $form['modules'][$module->getName()]['#required_by'][] = $name;
           $form['uninstall'][$module->getName()]['#disabled'] = TRUE;