diff --git context.module context.module
index ea1ef30..0de8972 100644
--- context.module
+++ context.module
@@ -518,3 +518,14 @@ function context_block_view_alter(&$data, $block) {
     $data['content']['#markup'] = "<div class='context-block-empty'>". t('This block appears empty when displayed on this page.') . "</div>";
   }
 }
+
+/**
+ * implement hook_page_alter()
+ *
+ * used for region context
+ */
+function context_page_alter(&$page) {
+  if ($plugin = context_get_plugin('reaction', 'region')) {
+    $plugin->execute($page);
+  }
+}
diff --git context.plugins.inc context.plugins.inc
index d5f18f7..b8b7d34 100644
--- context.plugins.inc
+++ context.plugins.inc
@@ -88,6 +88,11 @@ function _context_context_registry() {
       'description' => t('Control block visibility using context.'),
       'plugin' => 'context_reaction_block',
     ),
+    'region' => array(
+      'title' => t('Regions'),
+      'description' => t('Control Region visiblity using context.'),
+      'plugin' => 'context_reaction_region',
+    ),
     'breadcrumb' => array(
       'title' => t('Breadcrumb'),
       'description' => t('Set the breadcrumb trail to the selected menu item.'),
@@ -273,6 +278,14 @@ function _context_context_plugins() {
       'parent' => 'context_reaction',
     ),
   );
+  $plugins['context_reaction_region'] = array(
+    'handler' => array(
+      'path' => drupal_get_path('module', 'context') .'/plugins',
+      'file' => 'context_reaction_region.inc',
+      'class' => 'context_reaction_region',
+      'parent' => 'context_reaction',
+    ),
+  );
   $plugins['context_reaction_breadcrumb'] = array(
     'handler' => array(
       'path' => drupal_get_path('module', 'context') .'/plugins',
diff --git plugins/context_reaction_region.inc plugins/context_reaction_region.inc
new file mode 100644
index 0000000..0544716
--- /dev/null
+++ plugins/context_reaction_region.inc
@@ -0,0 +1,46 @@
+<?php
+
+class context_reaction_region extends context_reaction {
+
+  function editor_form($context) {
+  }
+
+  function options_form($context) {
+    $values = $this->fetch_from_context($context);
+    $form = array();
+    foreach (list_themes() as $theme) {
+      if ($theme->status) {
+        $regions = system_region_list($theme->name);
+        $default = isset($values[$theme->name]) ? $values[$theme->name] : array();
+
+        $form[$theme->name."_set"] = array(
+          '#type' => 'fieldset',
+          '#title' => "Disable Regions in {$theme->name} Theme",
+          '#collapsible' => TRUE,
+          '#collapsed' => !array_reduce($default, create_function('$a, $b','return $a || $b;')), 
+        );
+        $form[$theme->name ."_set"][$theme->name] = array(
+          '#type' => 'checkboxes',
+          '#title' => "Disable the following",
+          '#options' => $regions,
+          '#default_value' => $default,
+        );
+      }
+    }
+    return $form;
+  }
+  
+  function execute(&$page) {  
+    global $theme;
+    foreach ($this->get_contexts() as $k => $v) { 
+      if (isset($v->reactions[$this->plugin][$theme])) {
+        $regions = $v->reactions[$this->plugin][$theme];
+        foreach($regions as $region => $disable) {
+          if ($disable && isset($page[$region])) {
+            unset($page[$region]);
+          }
+        }
+      }
+    }
+  }
+}
diff --git tests/context.reactions.test tests/context.reactions.test
index 42bcfa6..12917ad 100644
--- tests/context.reactions.test
+++ tests/context.reactions.test
@@ -227,3 +227,46 @@ class ContextReactionThemeHtmlTest extends DrupalWebTestCase {
     context_delete($context);
   }
 }
+
+class ContextReactionRegionTest extends DrupalWebTestCase {
+  protected $profile = 'testing';
+
+  public static function getInfo() {
+    return array(
+      'name' => 'Reaction: Region',
+      'description' => 'Test Region disable reaction.',
+      'group' => 'Context',
+    );
+  }
+
+  function setUp() {
+    parent::setUp('context', 'ctools');
+    $admin_user = $this->drupalCreateUser(array(
+      'access administration pages',
+      'administer nodes',
+      'administer site configuration'
+    ));
+    $this->drupalLogin($admin_user);
+  }
+
+  function test() {
+    ctools_include('export');
+    theme_enable(array('bartik'));
+    variable_set('theme_default', 'bartik');
+    global $theme;
+    $context = ctools_export_new_object('context');
+    $context->name = 'testcontext';
+    $context->conditions = array('sitewide' => array('values' => array(1)));
+    $context->reactions = array('region' => array( 'bartik' => array('content' => 'Content')));
+    $saved = context_save($context);
+    $this->assertTrue($saved, "Context 'testcontext' saved.");
+
+    $output = $this->drupalGet('node');
+    $this->assertNoRaw('first-time');
+    $this->assertNoRaw('pager');
+
+
+    // Cleanup
+    context_delete($context);
+  }
+}